Paula’s Choice – 25% Vitamin C + Glutathione Clinical Serum – 30 ML
A high-potency clinical serum featuring a 25% stable Vitamin C blend and Glutathione. Engineered to target stubborn discoloration and improve skin elasticity without the “sting” often associated with high-dose Vitamin C.
Targets Dark spots/hyperpigmentation, Dullness, Uneven Skin Tone
Suited to All Skin Types
Format Serum
Description
The 25% Vitamin C + Glutathione Clinical Serum is a masterclass in stability and skin-deep delivery. Unlike standard formulas that rely on volatile L-Ascorbic Acid, this serum utilizes a sophisticated blend of 25% oil-and-water soluble Vitamin C (Tetrahexyldecyl Ascorbate and Ascorbyl Glucoside). This dual-solubility allows the actives to penetrate the skin’s uppermost layers more effectively, ensuring that the brightening and firming benefits stay consistent throughout the day.
To balance such a high concentration, Paula’s Choice integrated GAP Technology—a specialized system of glutathione amino acid precursors. This works alongside Glutathione to reduce oxidative stress and act as a “booster” for the Vitamin C, keeping the formula stable while minimizing the risk of irritation. The result is a clinical-level treatment that visibly fades sun damage and post-blemish marks while promoting a pro-collagen environment for firmer, more resilient skin.
Lightweight and hydrating, this serum is enriched with Apple Fruit Extract and Ergothioneine to provide extra antioxidant defense against environmental pollutants. It is an ideal solution for all skin types looking to graduate to a professional-strength brightening routine without compromising the skin barrier.
How to use:
- Apply a small amount to the face and neck after cleansing, toning, and exfoliating.
- For optimal results, use in both your AM and PM routines.
- Layering Tip: This serum has a lightweight, creamy texture that plays well with other boosters. Apply before your moisturizer.
- Sun Protection: Because Vitamin C works best when shielded from UV rays, always follow with an SPF 30+ during the day.
- Note: While this formula is designed to be non-irritating, if you are a Vitamin C beginner, you may want to introduce it every other day before moving to twice-daily use.

















